Publications and Posters

Please contact us to for more information on our recent publications and conference posters. 


Peer-reviewed Publications

Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring

Yennemadi AS, Jameson G, Glass M, De Pasquale C, Keane J, Bianchi M, Leisching G.  Cell Immunol. 2023 Aug;390:104741. doi: 10.1016/j.cellimm.2023.104741. Epub 2023 Jun 20. PMID: 37356269.


Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting. 

Barbiero I, Bianchi M, Kilstrup-Nielsen C. J Neuroendocrinol. 2022 Feb;34(2):e13033. doi: 10.1111/jne.13033. Epub 2021 Sep 8.PMID: 34495563  


Pregnenolone-methyl-ether enhances CLIP170 and microtubule functions improving spine maturation and hippocampal deficits related to CDKL5 deficiency. 

Barbiero I, Zamberletti E, Tramarin M, Gabaglio M, Peroni D, De Rosa R, Baldin S, Bianchi M, Rubino T, Kilstrup-Nielsen C. Hum Mol Genet. 2022 Aug 23;31(16):2738-2750. doi: 10.1093/hmg/ddac067.PMID: 35348691 


Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether. 

De Rosa R, Valastro S, Cambria C, Barbiero I, Puricelli C, Tramarin M, Randi S, Bianchi M, Antonucci F, Kilstrup-Nielsen C. Int J Mol Sci. 2022 Dec 21;24(1):68. doi: 10.3390/ijms24010068.PMID: 36613509   


Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats. 

Garrone B, Durando L, Prenderville J, Sokolowska E, Milanese C, Di Giorgio FP, Callaghan C, Bianchi M. Sci Rep. 2021 May 12;11(1):10139. doi: 10.1038/s41598-021-89629-y.PMID: 33980934   


Pregnenolone and pregnenolone-methyl-ether rescue neuronal defects caused by dysfunctional CLIP170 in a neuronal model of CDKL5 Deficiency Disorder. 

Barbiero I, Peroni D, Siniscalchi P, Rusconi L, Tramarin M, De Rosa R, Motta P, Bianchi M, Kilstrup-Nielsen C. Neuropharmacology. 2020 Mar 1;164:107897. doi: 10.1016/j.neuropharm.2019.107897. Epub 2019 Nov 30. 


American Society for Clinical Psychopharmacology 2024 – Poster

a-Tubulin Post-translational Modifications as Potential Translational Biomarkers in Major Depressive Disorder

Waninger, S., Freeburn, A., Kealy, J. & Bianchi, M.


Society for Neuroscience 2022 – Posters

A synucleinopathy rat model as a tool to investigate synaptic dysfunction and neuroinflammation in Parkinson’s Disease.

Freeburn, A., Tello, J., Disha, D., McGurk, C., Koprich, J.B., M. Brotchie, J.M., Pusung, A., Hill, M.P., & Bianchi, M. 


Acetylated alpha-tubulin and neurofilament light chain as a clinical plasma biomarkers of Charcot-Marie-Tooth Disease. 

Kealy, J., Freeburn, A., Disha, D., Onishi, T., Otake, K., Tanaka, M., Iwashita, H., Suzuki, A., Togher, Z., Murphy, S.M & Bianchi, M. 


#ThinkRare – Biomarker analysis to bridge preclinical and clinical research in rare neurodevelopmental disorders like CDKL5 Deficiency Disorder and Fragile X Syndrome. 

Bianchi, M., Kealy, J., Thornton, A., Callaghan, C.K., Freeburn, A., Disha, D., McGurk, C., Connolly, C., Traini, F., Kilstrup-Nielson, C., Barbiero, I., Garrone, B., Milanese, C., & di Giorgio, F.


The interferon-alpha rat model of neuroinflammation as a back-translational model of depression to investigate the efficacy of antidepressant and anti-inflammatory drugs. 

Kealy, J., de Pasquale, C., Freeburn, A., Glass, M., Disha, D., Murray, K., Callaghan, C.K., & Bianchi, M.


Clinical Team Posters

#ThinkRare – Harnessing the power of advocacy and community engagement for biomarker and clinical research.

de Pasquale, C., Traini, F., Freeburn, A., Connolly, C., Bianchi, M., & Kealy, J.


Syrens: A Neurolinguistic study to assess cognitive abilities and develop composite biomarkers in Fragile X Premutation Carriers

Traini, F., Kealy, J., O’Mara, S., & Bianchi, M.


Ulysses in the News

Oct 2022: Ulysses Neuroscience aims to raise €1.5m for expansion 


Nov 2021: The doctor told me not to worry, but I knew there was something wrong with my beautiful new baby


Oct 2021: Trinity neuroscientists developing potential novel treatments for rare genetic disorder in children